References of Oral Food Challenges or Double-Blind Placebo-Controlled Food Challenges (DBPCFCs),

Oral food challenges are procedures conducted to make an accurate diagnosis of immediate, and occasionally delayed, adverse reactions to foods. The timing of the challenge is carefully chosen based on the individual patient history and the results of skin prick tests and food specific serum IgE values. The type of the challenge is determined by the history, the age of the patient, and the likelihood of encountering subjective reactions. The food challenge requires preparation of the patient for the procedure and preparation of the office for the organized conduct of the challenge, for a careful assessment of the symptoms and signs and the treatment of reactions. The starting dose, the escalation of the dosing, and the intervals between doses are determined based on experience and the patient’s history. The interpretation of the results of the challenge and arragements for follow-up after a challenge are important. A negative oral food challenge result allows introduction of the food into the diet, whereas a positive oral food challenge result provides a sound basis for continued avoidance of the food.

Diagnostic oral food challenges (OFCs), introduced in clinical practice by May 1976 in the form of double-blind, placebo-controlled food challenges (DBPCFCs), are procedures that may be used to establish definitively whether a food is the cause of adverse reactions. They are used as clinically indicated, either at initial diagnosis or during follow-up. This article is intended to provide a practical and comprehensive guide to aid allergists/immunologists, who are uniquely qualified to perform diagnostic OFCs, in the use of the procedure for patient care in a scientifically sound, safe, and practical manner. It describes approaches used by allergists/immunologists in the United States and incorporates critically reviewed published international experience. Additional resources are “Food Allergy: A Practice Parameter” and “A Health Professional’s Guide to Office Food Challenges.”

Decision process regarding selection of open vs blind OFCs. Blinded portions of the OFC must always be followed by an open feeding with an age-appropriate serving of food in its natural form or the least cooked/baked/processed form of food that will be incorporated into the patient’s diet at home. source: American Academy of Allergy, Asthma & Immunology


  • Sicherer SH,  Sampson HA. Food allergy. J Allergy Clin Immunol. 2006;117(2      suppl mini-primer):S470–S475
  • Untersmayr      E, Vestergaard H, Malling HJ, et al. Incomplete digestion of codfish      represents a risk factor for anaphylaxis in patients with allergy. J      Allergy Clin Immunol. 2007;119:711–717
  • Fukutomi O,      Kondo N, Agata H, Shinoda S, Shinbara M, Orii T. Abnormal responses of      the autonomic nervous system in food-dependent exercise-induced      anaphylaxis. Ann Allergy. 1992;68:438–445
  • Juji F, Suko      M. Effectiveness of disodium cromoglycate in food-dependent,      exercise-induced anaphylaxis: a case report. Ann Allergy. 1994;72:452–454
  • Katsunuma T,      Iikura Y, Akasawa A, Iwasaki A, Hashimoto K, Akimoto K. Wheat-dependent      exercise-induced anaphylaxis: inhibition by sodium bicarbonate. Ann      Allergy. 1992;68:184–188
  • Palosuo K,      Varjonen E, Nurkkala J, et al. Transglutaminase-mediated cross-linking      of a peptic fraction of omega-5 gliadin enhances IgE reactivity in      wheat-dependent, exercise-induced anaphylaxis. J Allergy Clin      Immunol. 2003;111:1386–1392
  • Palosuo K. Update  on wheat hypersensitivity. Curr Opin Allergy Clin Immunol. 2003;3:205–209
  • Harada S,      Horikawa T, Ashida M, Kamo T, Nishioka E, Ichihashi M. Aspirin enhances      the induction of type I allergic symptoms when combined with food and      exercise in patients with food-dependent exercise-induced anaphylaxis. Br      J Dermatol. 2001;145:336–339
  • Bock SA, Sampson HA, Atkins FM,      et al. Double-blind, placebo-controlled food challenge (DBPCFC) as an      office procedure: a manual. J Allergy Clin Immunol. 1988;82:986–997
  • Bindslev-Jensen      C, Ballmer-Weber BK, Bengtsson U, et al. Standardization of food      challenges in patients with immediate reactions to foods—position paper      from the European Academy of Allergology and Clinical Immunology. Allergy.      2004;59:690–697
  • Bahna SL. Food      challenge procedure: optimal choices for clinical practice. Allergy      Asthma Proc. 2007;28:640–646
  • Chapman JA,      Bernstein IL, Lee RI, Oppenhemier J. Food allergy. a practice parameter.      Ann Allergy Asthma Immunol. 2006;96(3 suppl 2):
  • Crevel RW,      Ballmer-Weber BK, Holzhauser T, et al. Thresholds for food allergens      and their value to different stakeholders. Allergy. 2008;63:597–609
  • Mofidi S,      Bock SA. A health professional’s guide to food challenges. Fairfax      (VA): Food Allergy and Anaphylaxis Network; 2004;
  • Sampson MA,      Munoz-Furlong A, Sicherer SH. Risk-taking and coping strategies of      adolescents and young adults with food allergy. J Allergy Clin      Immunol. 2006;117:1440–1445
  • Primeau MN,      Kagan R, Joseph L, et al. The psychological burden of peanut allergy as      perceived by adults with peanut allergy and the parents of peanut-allergic      children. Clin Exp Allergy. 2000;30:1135–1143
  • Sicherer SH.      Beyond oral food challenges: improved modalities to diagnose food      hypersensitivity disorders. Curr Opin Allergy Clin Immunol. 2003;3:185–188
  • Sicherer SH,      Teuber S. Current approach to the diagnosis and management of adverse      reactions to foods. J Allergy Clin Immunol. 2004;114:1146–1150
  • Sicherer SH,      Bock SA. An expanding evidence base provides food for thought to avoid      indigestion in managing difficult dilemmas in food allergy. J      Allergy Clin Immunol. 2006;117:1419–1422
  • Fiedler EM,      Zuberbier T, Worm M. A combination of wheat flour, ethanol and food      additives inducing FDEIA. Allergy. 2002;57:1090–1091
  • Matsuo H,      Morimoto K, Akaki T, et al. Exercise and aspirin increase levels of      circulating gliadin peptides in patients with wheat-dependent      exercise-induced anaphylaxis. Clin Exp Allergy. 2005;35:461–466
  • Lieberman      PL, Kemp SF, Oppenheim JJ, Lang DM, Bernstein IL, Nicklas RAThe diagnosis      and management of anaphylaxis: an updated practice parameter. J Allergy      Clin Immunol. 2006;115:S483–S523
  • James JM,      Eigenman PA, Sampson HA, Eggleston PA. Airway reactivity changes in      asthmatic patients undergoing blinded food challenges. Am J Respir      Crit Care Med. 1996;153:597–603
  • Sampson HA,      Munoz-Furlong A, Campbell RL, et al. Second symposium on the definition      and management of anaphylaxis: summary report—second National Institute of      Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network      symposium. Ann Emerg Med. 2006;47:373–380
  • Sampson HA,      Mendelson L, Rosen JP. Fatal and near-fatal anaphylactic reactions to      food in children and adolescents. N Engl J Med. 1992;327:380–384
  • Lee JM,      Greenes DS. Biphasic anaphylactic reactions in pediatrics. Pediatrics.      2000;106:762–766
  • Taylor SL,      Hefle SL, Bindslev-Jensen C, et al. Factors affecting the determination      of threshold doses for allergenic foods: how much is too much?. J      Allergy Clin Immunol. 2002;109:24–30
  • Chinchilli      VM, Fisher L, Craig TJ. Statistical issues in clinical trials that      involve the double-blind, placebo-controlled food challenge. J      Allergy Clin Immunol. 2005;115:592–597
  • Garcia-Ara      C, Boyano-Martinez T, Diaz-Pena JM, et al. Specific-IgE levels in the      diagnosis of immediate hypersensitivity to cow’s milk protein in the      infant. J Allergy Clin Immunol. 2001;107:185–190
  • Boyano-Martinez      T, Garcia-Ara C, Diaz-Pena JM, Martin-Esteban M. Prediction of      tolerance on the basis of quantification of egg white-specific IgE      antibodies in children with egg allergy. J Allergy Clin Immunol.      2002;110:304–309
  • Bush RK,      Zoratti E, Taylor SL. Diagnosis of sulfite and aspirin sensitivity. Clin      Rev Allergy. 1990;8:159–178
  • Osterballe      M, Bindslev-Jensen C. Threshold levels in food challenge and specific      IgE in patients with egg allergy: is there a relationship?. J      Allergy Clin Immunol. 2003;112:196–201
  • Ballmer-Weber      BK, Holzhauser T, Scibilia J, et al. Clinical characteristics of      soybean allergy in Europe: a double-blind, placebo-controlled food      challenge study. J Allergy Clin Immunol. 2007;119:1489–1496
  • Bernstein      IL, Li JT, Bernstein DI, Hamilton R, Spector SL, Tan R, et al. Practice      parameters for allergy diagnostic testing. Ann Allergy. 1995;75:543–625
  • The official      statement of the American Thoracic Society . guidelines for      methacholine and exercise challenge testing—1999. Am J Respir Crit      Care Med. 2000;161:309–329
  • Bernstein      IL, Li JT, Bernstein DI, et al. Allergy diagnostic testing: an updated      practice parameter. Ann Allergy Asthma Immunol. 2008;100(3      suppl. 3):S1–S148
  • Sampson HA,      Ho DG. Relationship between food-specific IgE concentrations and the      risk of positive food challenges in children and adolescents. J      Allergy Clin Immunol. 1997;100:444–451
  • Sampson HA. Utility      of food-specific IgE concentrations in predicting symptomatic food      allergy. J Allergy Clin Immunol. 2001;107:891–896
  • Roberts G,      Lack G. Diagnosing peanut allergy with skin prick and specific IgE      testing. J Allergy Clin Immunol. 2005;115:1291–1296
  • Niggemann B,      Rolinck-Werninghaus C, Mehl A, Binder C, Ziegert M, Beyer K. Controlled      oral food challenges in children—when indicated, when superfluous?. Allergy.      2005;60:865–870
  • Verstege A,      Mehl A, Rolinck-Werninghaus C, et al. The predictive value of the skin      prick test weal size for the outcome of oral food challenges. Clin      Exp Allergy. 2005;35:1220–1226
  • Mehl A,      Rolinck-Werninghaus C, Staden U, et al. The atopy patch test in the      diagnostic workup of suspected food-related symptoms in children. J      Allergy Clin Immunol. 2006;118:923–929
  • Sporik R,      Hill DJ, Hosking CS. Specificity of allergen skin testing in predicting      positive open food challenges to milk, egg, and peanut in children. Clin      Exp Allergy. 2000;30:1540–1546
  • Knight AK,      Shreffler WG, Sampson HA, et al. Skin prick test to egg white provides      additional diagnostic utility to serum egg white-specific IgE antibody      concentration in children. J Allergy Clin Immunol. 2006;117:842–847
  • Perry TT,      Matsui EC, Kay Conover-Walker M, Wood RA. The relationship of      allergen-specific IgE levels and oral food challenge outcome. J      Allergy Clin Immunol. 2004;114:144–149
  • Sicherer SH,      Morrow EH, Sampson HA. Dose-response in double-blind,      placebo-controlled oral food challenges in children with atopic      dermatitis. J Allergy Clin Immunol. 2000;105:582–586
  • Bahna SL. Blind      food challenge testing with wide-open eyes. Ann Allergy. 1994;72:235–238
  • Huijbers GB,      Colen AA, Jansen JJ, Kardinaal AF, Vlieg-Boerstra BJ, Martens BP. Masking      foods for food challenge: practical aspects of masking foods for a      double-blind, placebo-controlled food challenge. J Am Diet Assoc.      1994;94:645–649
  • Pastorello      EA, Pravettoni V, Stocchi L, Bigi A, Schilke ML, Zanussi C. Are      double-blind food challenges necessary before starting an elimination      diet?. Allergy Proc. 1991;12:319–325
  • Rodriguez J,      Crespo JF, Burks W, et al. Randomized, double-blind, cross-over      challenge study in 53 subjects reporting adverse reactions to melon      (Cucumis melo). J Allergy Clin Immunology. 2000;106:968–972
  • Vlieg-Boerstra      BJ, Bijleveld CM, van der Heide S, et al. Development and validation of      challenge materials for double-blind, placebo-controlled food challenges      in children. J Allergy Clin Immunol. 2004;113:341–346
  • Briggs D,      Aspinall L, Dickens A, Bindslev-Jensen C. Statistical model for      assessing the proportion of subjects with subjective sensitisations in      adverse reactions to foods. Allergy. 2001;56(suppl 67):83–85
  • Gellerstedt      M, Magnusson J, Grajo U, Ahlstedt S, Bengtsson U. Interpretation of      subjective symptoms in double-blind placebo-controlled food      challenges—interobserver reliability. Allergy. 2004;59:354–356
  • Gellerstedt      M. Statistical issues—significantly important in medical research. Allergy.      2002;57:76–82
  • Hourihane      JO’B, Kilburn SA, Nordlee JA, Hefle SL, Taylor SL, Warner JO. An      evaluation of the sensitivity of subjects with peanut allergy to very low      doses of peanut protein: a randomized, double-blind, placebo-controlled      food challenge study. J Allergy Clin Immunol. 1997;100:596–600
  • Sicherer SH.      Food allergy: when and how to perform oral food challenges. Pediatr      Allergy Immunol. 1999;10:226–234
  • Wensing M,      Penninks AH, Hefle SL, et al. The range of minimum provoking doses in      hazelnut-allergic patients as determined by double-blind,      placebo-controlled food challenges. Clin Exp Allergy. 2002;32:1757–1762
  • Werfel T,      Ahlers G, Schmidt P, Boeker M, Kapp A, Neumann C. Milk-responsive      atopic dermatitis is associated with a casein-specific lymphocyte response      in adolescent and adult patients. J Allergy Clin Immunol. 1997;99(1      pt 1):124–133
  • Rautava S,      Isolauri E. Cow’s milk allergy in infants with atopic eczema is      associated with aberrant production of interleukin-4 during oral cow’s      milk challenge. J Pediatr Gastroenterol Nutr. 2004;39:529–535
  • Sicherer SH,      Noone SA, Koerner CB, Christie L, Burks AW, Sampson HA. Hypoallergenicity      and efficacy of an amino acid-based formula in children with cow’s milk      and multiple food hypersensitivities. J Pediatr. 2001;138:688–693
  • Bock SA,      Atkins FM. The natural history of peanut allergy. J Allergy Clin      Immunol. 1989;83:900–904
  • Conners CK. A      teacher rating scale for use in drug studies with children. Am J      Psychiatry. 1969;126:884–888
  • Goyette CH,      Conners CK, Ulrich RF. Normative data on revised Conners Parent and      Teacher Rating Scales. J Abnorm Child Psychol. 1978;6:221–236
  • Thomas K,      Herouet-Guicheney C, Ladics G, et al. Evaluating the effect of food      processing on the potential human allergenicity of novel proteins:      international workshop report. Food Chem Toxicol. 2007;45:1116–1122
  • Eigenmann PA.      Anaphylactic reactions to raw eggs after negative challenges with      cooked eggs. J Allergy Clin Immunol. 2000;105:587–588
  • Des RA,      Nguyen M, Paradis L, Primeau MN, Singer S. Tolerance to cooked egg in      an egg allergic population. Allergy. 2006;61:900–901
  • Urisu A,      Ando H, Morita Y, et al. Allergenic activity of heated and      ovomucoid-depleted egg white. J Allergy Clin Immunol. 1997;100:171–176
  • Werfel SJ,      Cooke SK, Sampson HA. Clinical reactivity to beef in children allergic      to cow’s milk. J Allergy Clin Immunol. 1997;99:293–300
  • Eigenmann PA.      Anaphylaxis to cow’s milk and beef meat proteins. Ann Allergy      Asthma Immunol. 2002;89(6 suppl. 1):61–64
  • Ballmer-Weber      BK, Wuthrich B, Wangorsch A, Fotisch K, Altmann F, Vieths S. Carrot      allergy: double-blinded, placebo-controlled food challenge and      identification of allergens. J Allergy Clin Immunol. 2001;108:301–307
  • Samson KT,      Chen FH, Miura K, et al. IgE binding to raw and boiled shrimp proteins      in atopic and nonatopic patients with adverse reactions to shrimp. Int      Arch Allergy Immunol. 2004;133:225–232
  • Fiocchi A,      Restani P, Riva E, et al. Heat treatment modifies the allergenicity of      beef and bovine serum albumin. Allergy. 1998;53:798–802
  • Bernhisel-Broadbent      J, Scanlon SM, Sampson HA. Fish hypersensitivity, I: in vitro and oral      challenge results in fish-allergic patients. J Allergy Clin Immunol.      1992;89:730–737
  • Ballmer-Weber      BK, Hoffmann A, Wuthrich B, et al. Influence of food processing on the      allergenicity of celery: DBPCFC with celery spice and cooked celery in      patients with celery allergy. Allergy. 2002;57:228–235
  • Bernhisel-Broadbent      J, Strause D, Sampson HA. Fish hypersensitivity, II: clinical relevance      of altered fish allergenicity caused by various preparation methods. J      Allergy Clin Immunol. 1992;90(4 pt 1):622–629
  • van OJ,      Ahlstedt S, Bengtsson U, Borres MP, Hulthen L. Double-blind      placebo-controlled challenges for peanut allergy the efficiency of      blinding procedures and the allergenic activity of peanut availability in      the recipes. Allergy. 2005;60:602–605
  • Grimshaw KE,      King RM, Nordlee JA, Hefle SL, Warner JO, Hourihane JO. Presentation of      allergen in different food preparations affects the nature of the allergic      reaction—a case series. Clin Exp Allergy. 2003;33:1581–1585
  • Teuber SS. Hypothesis:      the protein body effect and other aspects of food matrix effects. Ann      N Y Acad Sci. 2002;964:111–116
  • Kelso JM,      Bardina L, Beyer K. Allergy to canned tuna. J Allergy Clin      Immunol. 2003;111:901
  • Skamstrup      HK, Vestergaard H, Stahl SP, et al. Double-blind, placebo-controlled      food challenge with apple. Allergy. 2001;56:109–117
  • Bolhaar ST,      van de Weg WE, van Ree R, et al. In vivo assessment with prick-to-prick      testing and double-blind, placebo-controlled food challenge of      allergenicity of apple cultivars. J Allergy Clin Immunol. 2005;116:1080–1086
  • Hsieh LS,      Moos M, Lin Y. Characterization of apple 18 and 31 kd allergens by      microsequencing and evaluation of their content during storage and      ripening. J Allergy Clin Immunol. 1995;96(6 pt 1):960–970
  • Sancho AI,      Foxall R, Browne T, et al. Effect of postharvest storage on the      expression of the apple allergen Mal d 1. J Agric Food Chem. 2006;54:5917–5923
  • Sancho AI,      Foxall R, Rigby NM, et al. Maturity and storage influence on the apple      (Malus domestica) allergen Mal d 3, a nonspecific lipid transfer protein. J      Agric Food Chem. 2006;54:5098–5104
  • Rodriguez J,      Crespo JF, Lopez-Rubio A, et al. Clinical cross-reactivity among foods      of the Rosaceae family. J Allergy Clin Immunology. 2000;106:183–189
  • Bolhaar ST,      Tiemessen MM, Zuidmeer L, et al. Efficacy of birch-pollen immunotherapy      on cross-reactive food allergy confirmed by skin tests and double-blind      food challenges. Clin Exp Allergy. 2004;34:761–769
  • Ballmer-Weber      BK, Vieths S, Luttkopf D, Heuschmann P, Wuthrich B. Celery allergy      confirmed by double-blind, placebo-controlled food challenge: a clinical      study in 32 subjects with a history of adverse reactions to celery root. J      Allergy Clin Immunol. 2000;106:373–378
  • Luttkopf D,      Ballmer-Weber BK, Wuthrich B, Vieths S. Celery allergens in patients      with positive double-blind placebo-controlled food challenge. J      Allergy Clin Immunol. 2000;106:390–399
  • Taylor SL,      Hefle SL. Ingredient and labeling issues associated with allergenic      foods. Allergy. 2001;56(suppl 67):64–69
  • Young E,      Patel S, Stoneham M, Rona R, Wilkinson JD. The prevalence of reaction      to food additives in a survey population. J R Coll Physicians Lond.      1987;21:241–247
  • Fuglsang G,      Madsen C, Saval P, Osterballe O. Prevalence of intolerance to food      additives among Danish school children. Pediatr Allergy Immunol.      1993;4:123–129
  • Volonakis M,      Katsarou-Katsari A, Stratigos J. Etiologic factors in childhood chronic      urticaria. Ann Allergy. 1992;69:61–65
  • Wilson BG,      Bahna SL. Adverse reactions to food additives. Ann Allergy      Asthma Immunol. 2005;95:499–507
  • Wuthrich B. Adverse      reactions to food additives. Ann Allergy. 1993;71:379–384
  • Simon RA. Sulfite      challenge for the diagnosis of sensitivity. Allergy Proc. 1989;10:357–362
  • Wuthrich B,      Kagi MK, Stucker W. Anaphylactic reactions to ingested carmine (E120). Allergy.      1997;52:1133–1137
  • Beaudouin E,      Kanny G, Lambert H, Fremont S, Moneret-Vautrin DA. Food anaphylaxis      following ingestion of carmine. Ann Allergy Asthma Immunol. 1995;74:427–430
  • Anibarro B,      Seoane J, Vila C, Mugica V, Lombardero M. Occupational asthma induced      by inhaled carmine among butchers. Int J Occup Med Environ Health.      2003;16:133–137
  • Nish WA,      Whisman BA, Goetz DW, Ramirez DA. Anaphylaxis to annatto dye: a case      report. Ann Allergy. 1991;66:129–131
  • Moneret-Vautrin      DA, Morisset M, Lemerdy P, Croizier A, Kanny G. Food allergy and IgE      sensitization caused by spices: CICBAA data (based on 589 cases of food      allergy). Allerg Immunol (Paris). 2002;34:135–140
  • Hegde VL,      Venkatesh YP. Anaphylaxis to excipient mannitol: evidence for an      immunoglobulin E-mediated mechanism. Clin Exp Allergy. 2004;34:1602–1609
  • Tarlo SM,      Dolovich J, Listgarten C. Anaphylaxis to carrageenan: a pseudo-latex      allergy. J Allergy Clin Immunol. 1995;95(5 pt 1):933–936
  • Howland WC,      Simon RA. Sulfite-treated lettuce challenges in sulfite-sensitive      subjects with asthma. J Allergy Clin Immunol. 1989;83:1079–1082
  • Geha RS,      Beiser A, Ren C, et al. Multicenter, double-blind, placebo-controlled,      multiple-challenge evaluation of reported reactions to monosodium      glutamate. J Allergy Clin Immunol. 2000;106:973–980
  • Geha RS,      Beiser A, Ren C, et al. Review of alleged reaction to monosodium      glutamate and outcome of a multicenter double-blind placebo-controlled      study. J Nutr. 2000;130(4S suppl):1058S–1062S
  • Stevenson      DD, Simon RA, Lumry WR, Mathison DA. Adverse reactions to tartrazine. J      Allergy Clin
  • Hourihane      JO, Grimshaw KE, Lewis SA, et al. Does severity of low-dose,      double-blind, placebo-controlled food challenges reflect severity of      allergic reactions to peanut in the community?. Clin Exp Allergy.      2005;35:1227–1233
  • Taylor SL,      Hefle SL, Bindslev-Jensen C, et al. A consensus protocol for the      determination of the threshold doses for allergenic foods: how much is too      much?. Clin Exp Allergy. 2004;34:689–695
  • Reekers R,      Busche M, Wittmann M, Kapp A, Werfel T. Birch pollen-related foods      trigger atopic dermatitis in patients with specific cutaneous T-cell      responses to birch pollen antigens. J Allergy Clin Immunol. 1999;104(2      pt 1):466–472
  • Niggemann B,      Wahn U, Sampson HA. Proposals for standardization of oral food      challenge tests in infants and children. Pediatr Allergy Immunol.      1994;5:11–13
  • Powell GK. Enterocolitis      in low-birth-weight infants associated with milk and soy protein intolerance.      J Pediatr. 1976;88:840–844
  • Powell GK. Milk-      and soy-induced enterocolitis of infancy. J Pediatr. 1978;93:553–560
  • Powell GK. Food      protein-induced enterocolitis of infancy: differential diagnosis and      management. Comp Ther. 1986;12:28–37
  • Sicherer SH,      Eigenmann PA, Sampson HA. Clinical features of food-protein-induced      enterocolitis syndrome. J Pediatr. 1998;133:214–219
  • Burks AW,      Casteel HB, Fiedorek SC, Willaims LW, Pumphrey CL. Prospective oral      food challenge study of two soybean protein isolates in patients with      possible milk or soy protein enterocolitis. Pediatr Allergy Immunol.      1994;5:40–45
  • Sicherer SH.      Food protein-induced enterocolitis syndrome: case presentations and      management lessons. J Allergy Clin Immunol. 2005;115:149–156
  • Perry TT,      Matsui EC, Conover-Walker MK, Wood RA. Risk of oral food challenges. J      Allergy Clin Immunol. 2004;114:1164–1168
  • Reibel S,      Rohr C, Ziegert M, Sommerfeld C, Wahn U, Niggemann B. What safety      measures need to be taken in oral food challenges in children?. Allergy.      2000;55:940–944
  • Busse PJ,      Nowak-Wegrzyn AH, Noone SA, Sampson HA, Sicherer SH. Recurrent peanut      allergy. N Engl J Med. 2002;347:1535–1536
  • Fleischer      DM, Conover-Walker MK, Christie L, Burks AW, Wood RA. The natural      progression of peanut allergy: resolution and the possibility of      recurrence. J Allergy Clin Immunol. 2003;112:183–189
  • Fleischer      DM, Conover-Walker MK, Christie L, Burks AW, Wood RA. Peanut allergy:      recurrence and its management. J Allergy Clin Immunol. 2004;114:1195–1201
  • Eigenmann      PA, Caubet JC, Zamora SA. Continuing food-avoidance diets after      negative food challenges. Pediatr Allergy Immunol. 2006;17:601–605
  • David TJ. Anaphylactic      shock during elimination diets for severe atopic eczema. Arch Dis      Child. 1984;59:983–986
  • Flinterman      AE, Knulst AC, Meijer Y, Bruijnzeel-Koomen CA, Pasmans SG. Acute allergic      reactions in children with AEDS after prolonged cow’s milk elimination      diets. Allergy. 2006;61:370–374
  • Bernstein M,      Day JH, Welsh A. Double-blind food challenge in the diagnosis of food      sensitivity in the adult. J Allergy Clin Immunol. 1982;70:205–210
  • Onorato J,      Merland N, Terral C, Michel FB, Bousquet J. Placebo-controlled      double-blind food challenge in asthma. J Allergy Clin Immunol. 1986;78:1139–1146
  • Daul CB,      Morgan JE, Hughes J, Lehrer SB. Provocation-challenge studies in      shrimp-sensitive individuals. J Allergy Clin Immunol. 1988;81:1180–1186
  • Scibilia J,      Pastorello EA, Zisa G, et al. Wheat allergy: a double-blind,      placebo-controlled study in adults. J Allergy Clin Immunol. 2006;117:433–439
  • Weichel M,      Vergoossen NJ, Bonomi S, et al. Screening the allergenic repertoires of      wheat and maize with sera from double-blind, placebo-controlled food      challenge positive patients. Allergy. 2006;61:128–135
  • Atkins FM,      Steinberg SS, Metcalfe DD. Evaluation of immediate adverse reactions to      foods in adult patients, II: a detailed analysis of reaction patterns      during oral food challenge. J Allergy Clin Immunol. 1985;75:356–363
  • Untersmayr      E, Bakos N, Scholl I, et al. Anti-ulcer drugs promote IgE formation      toward dietary antigens in adult patients. Faseb J. 2005;19:656–658
  • Scholl I,      Untersmayr E, Bakos N, et al. Antiulcer drugs promote oral      sensitization and hypersensitivity to hazelnut allergens in BALB/c mice      and humans. Am J Clin Nutr. 2005;81:154–160
  • Untersmayr      E, Focke M, Kinaciyan T, et al. Anaphylaxis to Russian beluga caviar. J      Allergy Clin Immunol. 2002;109:1034–1035
  • Untersmayr      E, Scholl I, Swoboda I, et al. Antacid medication inhibits digestion of      dietary proteins and causes food allergy: a fish allergy model in BALB/c      mice. J Allergy Clin Immunol. 2003;112:616–623
  • Untersmayr      E, Jensen-Jarolim E. The effect of gastric digestion on food allergy. Curr      Opin Allergy Clin Immunol. 2006;6:214–219

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Clinical and Editor in Chief :

Dr Widodo Judarwanto, pediatrician email :, Curiculum Vitae

Information on this web site is provided for informational purposes only and is not a substitute for professional medical advice. You should not use the information on this web site for diagnosing or treating a medical or health condition. You should carefully read all product packaging. If you have or suspect you have a medical problem, promptly contact your professional healthcare provider.

Copyright © 2012, Children Allergy Clinic Online Information Education Network. All rights reserved


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